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5e), which provides a possible explanation for the reduced carbon flux into the TCA

Additionally, these resistant strains exhibit increased sensitivity to oxidative stress (Mwenechanya et al., 2017)

Brock, J., Board, P

Specifically, while one study did not find a significant difference in GSSG levels in old relative to young adults (Yang et al., 1995), a second study reported increasing levels of GSSG (linear relationship) from 45 yrs of age (Jones et al., 2002)