Wang et al., 2023), including the amyloid hypothesis, copper toxicity (Wilkinson et al., 2004
And here, the thing that I tried to put forth in Super Agers was, we have an opportunity to prevent the big three age-related diseases like never before
Growth hormone treatment reduces abdominal visceral fat in postmenopausal women with abdominal obesity: a 12-month placebo-controlled trial
However, they increase risks of weight gain, osteoporosis, glucose intolerance, and susceptibility to infections with chronic use
Disorders of vascular permeability
Neurological Relevance Preclinical evidence suggests broader neuroprotective potential: In traumatic brain injury models, SS-31 reduced mitochondrial swelling, neuronal loss, and neuroinflammation Aged mice treated with SS-31 showed significantly improved exercise tolerance, muscle strength, and mitochondrial efficiency Studies demonstrate protection against ischemic injury and enhanced cardiac output Phase 3 trials are ongoing for dry age-related macular degeneration and primary mitochondrial myopathy (Stealth BioTherapeutics pipeline) Implications for Brain Aging Mitochondrial dysfunction is a hallmark of brain aging and neurodegeneration
