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CRC is a multifactorial disease, with modifiable risk factors such as high intake of processed or red meat, low consumption of dietary fiber, fruits, and vegetables, along with smoking, excessive alcohol use, and lack of physical activity [215]

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The RNA nanoparticles can be designed to contain a tumor-targeting ligand, resulting in specific uptake by the target cell type, while the drug payload is released via cleavage by esterases in the tumor microenvironment to ensure site-specific delivery

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