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Neither peptide is FDA-approved, and there is no registered trial of the combination
Vitamin B12 supplements can help treat or prevent a vitamin B12 deficiency, which can be serious and Not everyone needs to take a vitamin B12 supplement, as However, healthcare professionals may recommend vitamin B12 supplements for certain populations, including: people following a vegan diet older adults people who have had gastrointestinal surgery people who have nutrient absorption issues people with dietary restrictions People taking certain long-term medications, such as metformin and proton pump inhibitors, may also benefit from a supplement, as these medications can affect absorption of vitamin B12
PubMed Staresinic M, et al
These stem from impaired red blood cell production and nerve function, affecting oxygen transport and mental clarity.
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However, these patients had multiple risk factors for b12 deficiency beyond semaglutide use, including previous gastric surgery that permanently alters stomach anatomy and reduces intrinsic factor production
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