Humanized gnotobiotic mouse experiments C57BL/6JNarl male germ-free mice (812 weeks of age) were used to establish four study groups of hGM model through fecal microbiota transplantation (FMT) from donors of two OCCT-defined high-TMAO producers (O15 and O32) and two OCCT-defined low-TMAO producers (V12 and V25)
Preclinical data from a DHEA-induced PCOS rat model demonstrate that DNase I treatment reduces hepatic NET deposition and improves glucose metabolism [5]
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Future efforts focusing on public education and evidence-based policy interventions, such as regulating alcohol retail density, taxes, and prices, need to be implemented along with effective clinical strategies to reduce the burden of cancer related to alcohol abuse
Thromb Haemost 111:842850
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