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When combined with alpha-lipoic acid, some early research has shown that benfotiamine may enhance effects in reducing pain and improving nerve conduction in people with diabetic neuropathy.8 The synergy likely stems from their complementary mechanisms: benfotiamine helps manage glucose-induced damage, while ALA reduces oxidative stress and improves blood flow

Biochem Mosc 89(11):18891903 Mira RG, Lira M, Tapia-Rojas C, Rebolledo DL, Quintanilla RA, Cerpa W (2020) Effect of alcohol on hippocampal-dependent plasticity and behavior: role of glutamatergic synaptic transmission

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Int J Biol Sci Mitochondrial SIRT2-mediated CPT2 deacetylation prevents diabetic cardiomyopathy by impeding cardiac fatty acid oxidation

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