See Supplemental Figure 1&2
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Treatments vary depending on the severity and duration of the symptoms and whether there is a rapid progression of the symptoms such as neurologic defects or impaired mobility
The mechanism is plausible (direct delivery should theoretically accelerate results), but the evidence base is not comparable to what exists for topical application
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Severe vitamin D deficiency increases the risk of mood swings, depression, and fatigue, and is associated with serious illnesses such as cardiovascular disease and cancer