Yes, but start the injectable escalation protocol from the beginning (2.5mg weekly)
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In the trial-product estimand analysis (accounting for treatment adherence), reductions reached 22.7% and 2.3%, respectively, corresponding to an absolute weight loss of -21.6 kg with combination therapy
18 During the maternal-to-zygotic transition, histone Kla, especially H3K18la, regulates the expression of zygotic genome activation (ZGA) genes such as Ccnt1 and Dppa2 , promoting embryonic development at the late G2 phase of the 2-cell stage in mouse embryos
Furthermore, since AOD 9604 therapy does not significantly impact growth and only slightly affects hormone pathways, it is safe to use on a long-term basis with continued medical supervision