doi:10.1016/j.yrtph.2020.104665 Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JHS
Inspired by mussel adhesion proteins, DA endows the hydrogel with strong bioadhesion, enabling it to firmly adhere to the surface of articular cartilage [Figure 10E] for long-term retention
Not surface-level fixes
Lactylation of NLRP3 at lysine 245 enhances its stability, triggering cardiomyocyte pyroptosis and promoting myocardial ischemiareperfusion (I/R) injury
While hyperhomocysteinemia may increase the risk of cognitive impairment and age-related neurodegenerative disease (e.g., Alzheimers disease), it is not clear whether vitamin B 12 deficiency contributes to the risk of dementia in the elderly
The injectable route keeps the advantage of maximal bioavailability and precise systemic dose control