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Research indicates the anti-fibrotic effects may be mediated through suppression of transforming growth factor beta (TGF-) signaling, a major driver of pathological cardiac fibrosis, and reduced activation of cardiac fibroblasts

(1991) also proved that topical diclofenac gel is able to penetrate into the articular capsule of the knee, which is much thicker than the tunica albuginea of the penis [41]

(PubMed) Foster TC

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These changes occurred through direct effects on adipocyte biology rather than appetite suppression, as research models maintained normal feeding behavior while exhibiting significant reductions in individual adipocyte size