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Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)

Khng t tng liu dng khi cha c ch dn ca chuyn gia

In contrast, neurons prioritize maintaining ion gradients for electrical signaling, with mitochondria concentrated near synapses to support neurotransmitter release

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It is commonly used in hormone replacement therapy (HRT) to support growth hormone levels, which naturally decline with age

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