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One should consider the primary phase lesion and hemorrhaging that results from mechanical damage during SCI as well as the secondary phase lesion that lasts several hours or even several months and is accompanied by edema, hemorrhage, inflammation, and cytotoxic edema [4447] and may extend to the white matter area and lead to white matter degeneration and damage [48, 49]

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Ketone-based metabolic therapy: is increased nad+ a primary mechanism