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40, 41 The results are expressed as per mg protein

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Table 8: SARS-CoV-2 Mpro Amino Acid Substitutions That Reduce Nirmatrelvir Activity 3-Fold in Biochemical Assays In Clinical Trials Treatment-emergent substitutions were evaluated among subjects in clinical trials EPIC-HR/SR with sequence data available at both baseline and post-baseline visits (n=907 PAXLOVID-treated subjects, n=946 placebo-treated subjects)

Kralj et al., 2017)

212 Similarly, H4K12la enhances glutamate-cysteine ligase (GCLC) expression, which is crucial for glutathione synthesis and inhibiting lipid peroxidation, leading to chemoresistance in CRC stem cells by inhibiting ferroptosis