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[143], who showed that cardiac overexpression of MTs significantly protects the heart from diabetes-induced injury

A recent study on human intestinal organoids confirmed the downregulation of several genes responsible for ATP synthesis, assembly of mitochondrial complex I proteins and mitochondrial uncoupling proteins during 5-FU administration leading to overall mitochondrial dysfunction (Rodrigues et al

Haider HF, Bojic T, Ribeiro SF, Paco J, Hall DA, Szczepek AJ