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Regarding this association, possible biological mechanisms elucidating the impact of smoking on anxiety include an array of processes, including the dopaminergic system, gamma-aminobutyric acid, hypothalamic-pituitary-adrenal axis, serotonin, and monoamine oxidase 26-28

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If prevalence had decreased by 2% a year since 2000 this figure would have been 1.3 billion in 2010 and 2025

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