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These pathological pathways are probably mediated, at least in part, through NLRP3 inflammasome stimulation and mitochondrial disruption

Furthermore, lactate produced by glycolytic tumor and stromal cells acts as a signaling molecule that stimulates VEGF expression and enhances endothelial cell motility and tube formation, thereby linking metabolic waste accumulation to vascular remodeling (177)

Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

They act as mighty messengers, sending signals to cells and tissues to perform a full spectrum of essential biological functions

10.1158/1078-0432.ccr-08-1306 Clin

309 Recently, Met restricted diet (MRD) has been reported to have an important role in anti-tumor immune regulation