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Interestingly, exposure to air pollutants, which is known to lead to lung damage, leads to anxiety-related behaviour and depression-like behaviours in mice and leads to mood disorders in humans 15

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[21] Major anti-tobacco campaigns were widely broadcast by the Nazis until the demise of the regime in 1945

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Airway epithelial barrier dysfunction not only impairs the physical barrier activity of airway epithelium, but further exposes sub-epithelial layers to exogenous substances, leading to a series of pathological processes such as airway inflammation, airway remodeling, airway hyperresponsiveness and increasing the rate of COPD exacerbation [7, 8]