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This could be mitigated in a future study by ensuring prior to randomisation that participants can purchase their cigarette packs in their usual pack size (25 cigarettes) and a pack size of 20

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In studies by PMI and others (see links below), participants who switched from cigarettes to THS saw their levels of biomarkers of exposure to harmful chemicals reduce and the level of HDL-C increase

It is also noteworthy that among the 3 most cytotoxic vapours for HUVEC evaluated in the Putzhammer et al