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Lipoic acid might be able to increase glutathione synthesis in aged rats by up-regulating the expression of -glutamylcysteine ligase (-GCL), the rate-limiting enzyme in glutathione synthesis (31), and by increasing cellular uptake of cysteine, an amino acid required for glutathione synthesis (32)

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To, K., Cao, R., Yegiazaryan, A., Owens, J., Nguyen, T., Sasaninia, K., Venketaraman, V

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6t) show that loss of GSH induces a partial uncoupling of ETC from OXPHOS, suggesting that Gclc function has a direct effect on the metabolic dependencies of FoB