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For this group, the question is not whether nicotine is ideal, but whether safer nicotine alternatives, with dramatically lower toxicant exposure than cigarettes, may reduce risk for those who would otherwise continue smoking

Quantity: 30 pouches of 4 cigarillos each, totaling 120 cigarillos

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Quality assessment Study quality was appraised by three reviewers (N.A., E.T., and J-L.R.) using the Mixed Methods Appraisal Tool (MMAT) and two Indigenous frameworks (Additional File 2)

Addressing these lifestyle factors may not only reduce the occurrence of headaches but also contribute to overall well-being in the younger population