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Impaired mucociliary clearance, which can occur as a consequence of vaping, can lead to mucus accumulation in damaged lung tissue, causing drugs, like bronchodilators or inhaled corticosteroids (ICS), to remain in the airways longer, slowing clearance rate, increasing the local concentration and side effects and ultimately altering its efficacy (Winters et al

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A smoker is 12 13 times more likely to die due to COPD as compared to a nonsmoker