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Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers

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10.3389/fmicb.2019.02410 Front

It reinforces the importance of looking beyond simple sativa/indica classifications and focusing on the specific chemical composition

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