386 Increasing levels of nicotinamide adenine dinucleotide (NAD + ) precursors can improve symptoms of acquired muscle dysfunction by activating mitochondrial metabolism
Growth hormone secretagogues Compounds such as sermorelin a synthetic analogue of growth hormone-releasing hormone (GHRH) stimulate endogenous GH secretion
placebo in 184 patients with daily gluten challenge for 6 weeks, gastrointestinal symptoms and anti-tissue transglutaminase IgA antibodies were lower in the active treatment groups
doi: 10.1167/iovs.15-17201
In animal studies, AOD-9604 treatment reduced body weight gain by over 50% compared to controls over a 19-day period, with increased lipolytic activity in adipose tissue
Why there should be such striking differences in genetically identical individuals, in a disease caused by the same mutation, is unknown, but likely involves important epigenetic and environmental influences