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[3] Dosing of hydroxocobalamin should be individualized based on the severity of vitamin B deficiency and clinical response

Unlike appetite suppressants that work immediately, NNMT inhibition creates gradual metabolic changes that compound over time

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It reduces the potential gastrointestinal side effects

If tolerance is good and no adverse effects occur, increase to 75mg daily, often split into two doses of approximately 37.5mg each

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity