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Third, the identified differential metabolites and related pathways were not validated through in vivo and in vitro experiments

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doi:10.1057/palgrave.fp.8200087

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"It's a bit of a black mark on the cigarette industry that they haven't done this on their own accord." Warburton said BATA was reluctant to introduce the reduced-risk product out of concern that they would prompt smokers to become careless, leaving butts on beds or throwing them out of car windows