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The importance of this mechanism was highlighted by studies where supplementation with BH 4 improved endothelium-dependent vasorelaxation in chronic smokers [37] and in isolated blood vessels [38]

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We have been asked about it many times, too

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If we return to the example used in the media a disposable vape containing 2ml of 20mg/ml e-liquid could deliver as much nicotine as two packs of cigarettes (40 sticks total) so it seems there is some credibility to the claims made on social media and beyond