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DA dysfunction influences both cortical and subcortical circuitry, facilitating symptomatology of SZ differentially

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The shorter APD is caused by reduced inward L-type calcium (I CaL ) currents in PV cardiomyocytes, alongside greater outward delayed rectifier potassium (I K ) currents, causing the net current flow during the repolarization phase to be more outward (repolarizing) (38)

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Also, aging helps reduce the harshness of the raw tobacco, resulting in a smoother smoke