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When estimating the number of puffs of a vape is equal to a cigarette, the choice of nicotine concentration in the e-liquid plays a crucial role

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To check the robustness of the results, analysis was also conducted separately for the period 20182021, characterized by a high share of the illicit market [34], the COVID-19 pandemic, and the introduction of the indoor smoking ban in 2019 [37], and for the period outside this interval (S6 Table)

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Most case reports show that the health of children and adults can be negatively affected by EC products and that if death does not occur, negative effects can be reversed