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Key findings on cross-sensitization : Acute nicotine exposure sensitizes your brains locomotor response to amphetamine within hours Amphetamine pretreatment similarly augments nicotine-induced dopamine efflux in the striatum Adolescent nicotine exposure induces cross-sensitization to amphetamine that persists into adulthood This bidirectional enhancement means each substance primes your brain to respond more intensely to the other, accelerating dependency pathways