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Salgado RM, Marques-Silva MH, Gonalves E, Mathias AC, Aguiar JG, Wolff P

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When activated, Nrf2 disassociates from its repressor protein KEAP1 that reacts with oxidative radicals, translocates to the nucleus, binds to antioxidant response element and induces the transcription of defensive genes

An investigation conducted by Goldbraikh and colleagues revealed that the PI3K/AKT/Foxo3 signaling pathway is the primary mechanism responsible for controlling growth and metabolism in every cell (Goldbraikh et al

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[2] [3] Amylin is a pancreatic hormone not an incretin that plays a key role in slowing gastric emptying, reducing glucagon secretion, and promoting satiety