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This effect, combined with glucose-lowering medications, can result in symptomatic hypoglycemia characterized by shakiness, confusion, sweating, and in severe cases, loss of consciousness

Platelet interaction with activated endothelium: mechanistic insights from microfluidics

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Gylfadottir SS, Itani M, Kristensen AG, et al

It's just that the body's response to it is not, it's too much too strong

But it has zero direct effect on the hormonal signals that regulate appetite, satiety, or energy expenditure