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MK: Data curation, Writingoriginal draft

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Symptoms, which typically emerge before six months of age, include failure to thrive, decreased appetite, lethargy, anemia, and GI issues like diarrhea

S4 Hormone and Metabolic Modulators This section was updated to include antibodies against myostatin and myostatin precursors

Although the exact mechanism of cyclosporine nephrotoxicity remains unknown, its administration has been associated with in vivo reduction of GSH concentrations in the livers and kidneys of rats, which may be related to adverse effects of this immunosuppressive agent

Often, a combination approach works best