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Here, to address this hypothesis, we developed a mouse model of rapid, complete depletion of all adipose depots, including stable cBMAT, within 9 days by chronically delivering leptin directly into the brain via intracerebroventricular (ICV) injection

Statements Author contributions EK: Writing review & editing, Writing original draft, Project administration, Funding acquisition, Formal analysis

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In summary, the range of skin anesthetic options lets healthcare providers customize pain management