Noncanonical inflammasome activation by intracellular LPS independent of TLR4
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Orellana M, Rodrigo R, Varela N, Araya J, Poniachik J, Csendes A, Smok G, Videla LA (2006) Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients
Its initiation depends on intracellular iron overload, which serves as the key biochemical basis and trigger, ultimately leading to extensive membrane damage
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[DOI] [PubMed] [Google Scholar] Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM