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For example, cannabidiol (CBD) induces autophagic cell death in glioma cells by activating transient receptor potential vanilloid 4 (TRPV4) [65]

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Most patients start at 300 mcg/day and titrate toward 500 mcg/day

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3.2.1 PINK1/Parkin mediated mitophagy The pathway consisting of PINK1 and Parkin is a key participant in mitophagy, as well as the most common and classical pathway of autophagic mitochondria (Lazarou et al., 2015)