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However, three studies did not find any significant evidence of genotoxicity following nicotine e-cigarette exposure 33,40,41

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Insulin resistance is a state where the blood cells become less responsive to insulin, leading to higher blood sugar levels

Similarly, a study using a mouse model found that PNE produced hyperactivity that was associated with selective decreases in cingulate cortical volume and radial thickness and a decrease in drug-induced dopamine release in the frontal cortex [36]