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It is hypothesised that once an acute infection has dysregulated the hosts immune system, pathogens are capable of intracellular persistence where they escape immune surveillance (202)

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They are viewed as an intermediate model between 2D monolayers and animal models, as they preserve key features of tumors, especially the response to drug treatments ( Treating the Th- MYCN spheroids with the DPI-MitoQ combination showed a strong synergistic effect

A Comparative structural and functional study in young adult and middle aged rats