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The most studied mechanisms include: upregulation of growth hormone receptors in fibroblasts (increasing sensitivity to healing signals), activation of the FAK-paxillin pathway (promoting cell adhesion and migration), modulation of the nitric oxide system through Src-Caveolin-1-eNOS phosphorylation (enhancing vascular function), and dual activation of the Egr-1/NAB2 gene loop (promoting organized, non-chaotic blood vessel growth)

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Zhang L , Zhao R, Kamachi K, Gupta SK, Akiyama H, Andreeff M, Ishizawa J

Seasonal variation in thyroid function in over 7,000 healthy subjects in an Iodine-sufficient area and literature review