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Systems toxicology investigations indicated that nicotine exposure also affected metabolic pathways the in liver, including upregulation of fatty acid beta-oxidation, cholesterol synthesis, gluconeogenesis, and ketone body formation pathways

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available in various forms such as Khaini, Snus, Shammaah, Nass, or Naswar), dry snuff (powdered tobacco traditionally inhaled through the nose or taken orally) and chewing tobacco (placed in the mouth and either sucked or chewed [1]