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After the resolution of the deficiency, if patients show clinical or hematologic signs associated with polycythemia vera, it is recommended they undergo further evaluations

The primary objective is to evaluate whether mecobalamin (vitamin B 12 ), given as an intramuscular injection once a week for 12 weeks compared with placebo reduces pain sensitivity, that is, tolerance time (cold pressor test)

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Because your body stores B12, it can take some years before you see symptoms that you're low on it