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A study in 650 elderly men and women reported that the risk of elevated plasma homocysteine levels was significantly higher in those with lower cognitive function scores (72)

Intramuscular injection may be clinically preferable to oral supplementation in specific situations: For individuals whose bloodwork shows deficiency or insufficiency in B12, vitamin D, or other measurable nutrients, and who have not achieved adequate levels through oral means

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Robust human dose-finding data do not exist for this blend

"Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency"

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