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Age was categorised, rather than included as a continuous variable to avoid the inclusion of polynomial terms or smoothing functions (e.g., splines), and to better facilitate the interpretation of results across drug types co-used

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The term continues to appear in modern music, online communities, podcasts, educational articles, and social media discussions

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4 In 2015, 11.5% of the burden of cardiovascular disease in Australia was attributable to tobacco use