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Furthermore, N4 neutrophils showed an increased expression of cellular stress, senescence and apoptosis markers ( Gadd45b , Gadd45g , Ddit3 , Bax , Creg1 , Mdm2 ), suggesting that they represent aged neutrophils whereas N3 and N5 neutrophils seem to be more lately recruited ( Figure 3G )
153 The first finding was that the rates of periodontal disease severity (periodontal pocket depth (PPD) and bleeding on probing (BOP)) among EC smokers were significantly lower (42.5%) than in traditional smokers (72.5%), but were considerably higher as compared to non-smokers (28.2%)
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