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Microbial bile acid metabolites modulate gut ROR+ regulatory T cell homeostasis

Dempsey was the primary editor on this article and managed its editorial process and peer review in collaboration with the rest of the editorial team

This effect is mediated by a reduction in the synthesis of prostaglandins, which are cell-signaling molecules derived from the omega-6 fatty acid arachidonic acid via the action of the cyclooxygenase enzymes (Downie 1991

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Clinically, it manifests as gradual impairments in memory, cognition, language, and daily functioning, often accompanied by behavioral and emotional alterations (Alzheimer, 1907)