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Smoking was also particularly high among adults with serious psychological distress (SPD), compared to adults without SPD (24.9% vs

No one stayed long

Further, given the complex association between exposure and outcome, creating a latent variable (such as a combination of different VOCs or HPHCs) might better capture and depict the mediation more accurately.

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In summary, we identified distinct neural bases for the initiation and sustenance of substance use, represented by reduced GMV in the left and right vmPFC, respectively

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