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doi: 10.1128/CMR.00011-10 34 Cano-GarridoOSeras-FranzosoJGarcia-FruitosE
However, no differences were observed in isometric torque production, specific torque, or histological measures of myofiber cross-sectional area or collagen deposition across any treatment group
Inhibition or down-regulation of GDH expression leads to a reduction in -KG production, which in turn affects the normal physiological activity of the tumour in a manner that reduces energy supply
iv) non-cardiac pathologies, with severe progression, which can generate arrhythmias such as hemorrhages, various neoplasms, hematological diseases, post-surgical conditions, infectious diseases, neuropsychiatric disorders, gout, hyperuricemia, renal insufficiency, hepatic, pulmonary failure and multiorgan failure
Human efficacy data are limited
has current consulting and/or advisory board agreements: Amgen Inc., Astellas, Akros, Centocor (Janssen), Inc., Celgene Corp., Bristol-Myers Squibb Co., Beiersdorf, Inc., Abbott Labs (AbbVie), TEVA, Actelion, UCB, Novo Nordisk, Novartis, Dermipsor Ltd., Incyte, Pfizer, Canfite, Lilly, Coronado, Vertex, Karyopharm, CSL Behring Biotherapies for Life, GlaxoSmithKline, Xenoport, Catabasis, Meiji Seika Pharma Co., Ltd, Takeda, Mitsubishi, Tanabe Pharma Development America, Inc, Genentech, Baxalta, Kineta One, KPI Therapeutics, Crescendo Bioscience, Aclaris, Amicus, Reddy Labs
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