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Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected mice

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Once exocytosed from the neuronal soma or axonal terminals, it couples to its specific receptor (Neurokinin receptors -NKRs-), belongs to the GPCR family (Schelfhout et al., 2006)

Some factors that result in increased biosynthesis and "high normal" erythrocyte GSH levels include, but are not limited to, moderate alcohol consumption, smoking, regular physical exercise and acute exposure to toxic metals

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That is effective in the short term, but it comes with trade-offs: increased infection risk, bone density loss, hormonal disruption