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In 1977, the American Cancer Society took its fight against cigarette smoking to the public when it sponsored the Great American Smokeout, issuing a challenge to smokers to stop smoking for a day

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CSE induced degradation of NLRP3 protein was inhibited by MG132, a proteasome inhibitor, but not by a lysosomal inhibitor, leupeptin, confirming that the effect of CSE on NLRP3 protein occurs through the ubiquitin proteasome system (Fig

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