Through the activity of these enzymes, glutathione directly supports antioxidant activity, phase II detoxification, and the normal breakdown of metabolites, toxins, and other compounds in the body
BMC Health Serv Res 2019;19:919
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Its activity is regulated by various factors including oxidative stress levels, availability of NADPH (which links GR activity to glucose metabolism via the pentose phosphate pathway), and cellular energy status
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