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Introduction As the main psychoactive component of tobacco, nicotine is considered essential for dependence ( In an investigation of smokers ( In terms of psychoactive effects, three major alkaloids in cigarette smoke (nornicotine, anabasine, and R-anatabine) have been reported to activate 42 nAChR (a major subtype of nicotinic acetylcholine receptor expressed in the brain) and could result in increased midbrain DA release ( Some other mechanisms may help explain the increased attraction of cigarettes